St. Blasius was Bishop of Sebaste in Armenia and most of the accounts place his martyrdom in the reign of Licinius (about 316). As these reports may rest on old traditions which are bound up with the veneration of the saint in the Church liturgy, they are not to be absolutely rejected.

St. Blasius suffered martyrdom at the beginning of the fourth century. All the particulars concerning his life and martyrdom which are found in the Acts are purely legendary and have no claim to historical worth. There are besides various recensions of the text of the Acts. According to the legend Blasius was a physician at Sebaste before he was raised to the Episcopal see. At the time of the persecution under Licinius he was taken prisoner at the command of the governor, Agricolaus. The hunters of the governor found him in the wilderness in a cave to which he had retired and while in prison he performed a wonderful cure of a boy who had a fishbone in his throat and who was in danger of choking to death. After suffering various forms of torture St. Blasius was beheaded; the Acts relate also the martyrdom of seven women.

The veneration of the Oriental saint was brought at an early date into Europe, as is shown by the recitals in the historical martyrologies of the ninth century, and the Latin recension of the legend of St. Blasius; so that Blasius became one of the most popular saints. The actual reason for the unusual veneration has not yet been made clear. Most probably one ground was that according to the legend he was a physician and wonderful cures were ascribed to him; for this reason the faithful sought his help and intercession when ill. Numberless churches and altars were dedicated to him and many localities, including Taranto, Ragusa, the Abbey of St. Blasius in the Black Forest that claimed to possess some of his relics .He was also one of the Fourteen Holy Martyrs.